Licorice and cortisone

a two edged sword that can be used to great clinical advantage if used correctly and under supervision.

Licorice, particularly its active component glycyrrhizin, has been shown to potentiate the effects of corticosteroids. This interaction is clinically significant and warrants caution when licorice and corticosteroids are used concurrently.

The potentiating effects of licorice on corticosteroids are primarily due to the inhibition of the enzyme 11β-hydrox…